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Quasi-closed system A system is closed if there is no interaction with the external environment

The clinical manifestations of brucellosis range from asymptomatic to severe and include prolonged fever, night sweats, joint pain, fatigue, weight loss, abdominal discomfort, and hepatosplenomegaly, with complications such as endocarditis and neurological disorders (1214)

Funding This work was supported by the Projects of Medicine and Health Science Technology Development Program in Shandong Province [2016WS0499], Shandong Provincial Natural Science Foundation of China Grants [ZR2019PH025]

Topical application may help support the appearance of smoother, healthier-looking skin over time