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Pancreatitis and gallbladder issues: Severe abdominal pain that radiates to the back, nausea, fever, or vomiting while using GLP-1s may indicate inflammation of the pancreas, while upper right abdominal pain, jaundice, fever, and nausea can be due to gallbladder issues such as gallstones

Ford ES, Cunningham TJ, Giles WH, Croft JB

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In the body, IGF-1 can activate growth a multitude of bodily tissues, including the nerves, bone, kidneys, and liver