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10.12729/jbtr.2020.21.3.101 55 LiM.ShaoD.ZhouJ.GuJ.QinJ.LiX.et al (2022)
What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation
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It possesses anti-inflammatory properties, reducing the release of local inflammatory factors and thereby indirectly alleviating pain
Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial
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