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10.1023/a:1026107405399 Neurochem Res

In RP genetic mutations lead to death of rod photoreceptors, and as a significant number of rods is lost, then cones begin to degenerate 2

The number of migrated cells remarkably decreased when ERK1/2 signal pathways were blocked by its inhibitor PD98059 (Figure 7BC)

Likewise, E2, through the GPER, stimulates neurite outgrowth in hippocampal neurons from the E17 mouse fetal brain (141), indicating that it also plays a role in neurogenesis and the maturation of neural circuits in different brain structures