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"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes." New England Journal of Medicine , 385(6), 503-515

It may aggregate into clumps that the body cannot use

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There are also medications that can change the acidity of the urine, and by alkalinizing the urine in such a case the risk of kidney stone can be decreased (uric acid is more soluble in alkaline medium, so less likely to crystallize)