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Alterations in T-bet/GATA-3 ratios indicate SINs function in maintaining the equilibrium between Th1 and Th2 ( Through various pathways, SIN suppresses the M1 polarization in macrophages, leading to a decrease in the production and secretion of diverse chemokines and pro-inflammatory cytokines, including TNF- and IL-8 ( , MCP-1, MIF, and MMP-9, downregulated CD14 and TLR4 expression, and reduced intracellular free calcium release

3) Pine Bark Extract (French Pine Bark)

Aksoy S, Firat Y, Alpar R

Untargeted metabolomics analysis reveals spatial metabolic heterogeneity in different intestinal segments of type 1 diabetic mice

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