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Amylin and Calcitonin Receptor Pathway Satiety Enhancement Cagrilintide acts as a nonselective agonist of amylin receptors (AMY1R, AMY2R, AMY3R) and calcitonin receptor (CTR), mimicking the satiety-inducing effects of endogenous amylin[3]

Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, et al

As indicated above, astrocyte reactivity leads to different changes in the homeostasis of the glutamate transporters, which leads to hyperexcitability, excitotoxicity, andeventuallythe appearance of seizures [25,62] (Figure 5)

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