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Bile acids also promote colonic water secretion, through TGR5-mediated activation of adenylate cyclase, which stimulates chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) (174)

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Moreover, low to deficient riboflavin status is emerging as a much more widespread issue across the developed world than has previously been recognised (Reference McNulty, Pentieva and Ward8,Reference Troesch, Hoeft and McBurney118)

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