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1 Introduction Chronic kidney disease (CKD) represents a growing global health burden, with increasing mortality and disability-adjusted life years (DALYs) ( 2 Vitamin D metabolism and physiological functions Vitamin D is a fat-soluble prohormone that is synthesized primarily in the skin from 7-dehydrocholesterol under ultraviolet B (UVB) radiation, forming previtamin D, which is then thermally isomerized into cholecalciferol (vitamin D)

71 In another study, engineered Salmonella inhibited GPX4 expression, induced ferroptosis, and suppressed glioma growth both in vitro and in vivo

O-GlcNAcylation of alpha-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding