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If female mitochondria accumulate an excess of antioxidant capacity, further elevating GSH might free up excess NADPH to serve as a substrate for NADPH oxidase 2 (NOX2) in the generation of superoxide ions

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The clinical use case is narrower and depends heavily on the patients specific picture

458 Interestingly, iron levels are significantly increased in the gastrocnemius and tibialis anterior muscles in dystrophin-utrophin knockout mice, and treating these mice with the iron chelator DFO reduces both superoxide levels and the dystrophic pathology