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The importance of the PDHc to the maintenance of homeostasis is evident from the fact that, although diseases associated with deficiencies of the PDHc have been observed, affected individuals often do not survive to maturity

In one study [56] investigating the impact of NAC on noise-induced hearing loss in men ( n = 53) taking 1200 mg per day for 14 days led to a significant reduction of noise-induced temporary threshold shift, or the amount of hearing loss after a period of heightened noise exposure in a work setting relative to baseline, or pre-shift levels

Cytochrome 2E1 (CYP2E1) is the primary enzyme responsible for the conversion of acetaminophen to its toxic metabolite

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It prevents tyrosinase activity and boosts brightening