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However, this adaptation creates a dependency on continuous nutrient and energy supplies, beyond the well-documented glucose metabolism alterations, leading to enhanced production of amino acids and fatty acids to support tumor growth [79, 80]

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Studies in prediabetes suggest that IGFBP-1 shows normal levels before developing T2D [256]

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It has been demonstrated that OS was not present in HTN-I patients, and significantly, it was lower as compared to a healthy control group in an observational study with 355 subjects (Nuez-Sells et al., 2019)