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Particular emphasis is placed on rational design principles that consistently enhance brain bioavailability and therapeutic efficacy across models of Alzheimers disease, Parkinsons disease, multiple sclerosis, and related disorders

To inhibit glycolysis, 2-Deoxy-D-glucose (2-DG, Sigma D8375) or galactose (D-(+)-Galactose, Sigma G0750) was used at the indicated concentration

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Titrate: Increase by roughly 200 mcg every two weeks as tolerated (400 600 800 mcg)

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