Parseghian CM, Parikh NU, Wu JY, Jiang ZQ, Henderson L, Tian F, Pastor B, Ychou M, Raghav K, Dasari A, Fogelman DR, Katsiampoura AD, Menter DG, Wolff RA, Eng C, Overman MJ, Thierry AR, Gallick GE, Kopetz S
During this period researchers began identifying signalling pathways that regulate cellular ageing processes and the behaviour of senescent cells
El-Tounsi I, Zhao S, Younes A, Consoli U, Thomas E, Lynch D, Andreeff M
But scientists quickly realized its effects were far from localized
Analgesic amounts stimulated respiration via central mu1 receptors, cataleptic amounts depressed breathing and blunted the CO2 response, and the peptide lowered blood pressure documenting the dose-dependent opioid effects including respiratory depression