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Methods 185 , 166170 (2012)

Mitochondria are the primary source of intracellular ROS, and ROS modulator 1 is one of the key mitochondrial proteins involved in ROS production 36

Real-time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-up Probe with Aggregation-Induced Emission Characteristics

Whether they reflect dose-related issues, sourcing variability, or true pharmacological effects is unknown, precisely because the human data does not exist to answer that question