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K87pAcF had the highest affinity (13.7 nM), a 3.7-fold increase compared to the wild type (Fig

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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake

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More broadly, dietary polyphenols like gallic and ferulic acid are recognized for reversing aberrant epigenetic marksthey can inhibit DNA methyltransferases or HDACs, reactivating silenced tumor suppressor genes (153)