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In the US, there are Food and Drug Administration (FDA) compulsory manufacturing standards [45] and American E-liquid Manufacturing Standards Association (AEMSA) recommended manufacturing standards

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Comparatively, smoking a single tobacco cigarette causes acute bronchoconstriction, which has been attributed to an irritant effect of the smoke leading to cholinergically mediated reflex bronchospasm [25]

[18] Transportation, Economic Development, and Environmental Conservation (TED) Bill, Part L