Human data is still limited, so individual results vary which is exactly why this is done with monitoring rather than guesswork
Grace ND, West DM, Sargison ND
This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation
According to NICE guidance and standard UK clinical practice, patients with confirmed B12 deficiency and neurological symptoms typically require initial treatment with hydroxocobalamin injections
Also, in most people, methyl and adenosyl B12 can inter-convert easily, so the exclusive supplementation of methyl B12 is enough in most cases