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Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

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Brinca A T, Ramalhinho A C, Sousa , et al

IGFBP5 plays an active role in myoblast differentiation by binding to insulin growth factor II and upregulating its expression 71

In one clinical trial, 12 weeks of collagen (with vitamin C) significantly improved moisture and reduced wrinkles