Key Takeaways The standard initial dose for severe deficiency is 1,000 mcg intramuscularly daily or every other day
[DOI] [PubMed] [Google Scholar] 131.Villena JA, Viollet B, Andreelli F, Kahn A, Vaulont S, Sul HS
Mass and purity are verified vacuum sensation is not a validated quality metric
Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly
Source: Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia (2016) Remarkable improvements with B12 and folinic acid treatment