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Zinc is dynamically distributed within cells, where its compartmentalization across organelles, such as the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, lysosomes, endosomes and peroxisomes, enables specialized functions crucial for organelle integrity and interorganelle communication

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Among these, nanoparticles (20 - 200 nm) stand out for their enhanced solubility and targeted delivery capabilities, though they face challenges such as potential toxicity and clearance by the mononuclear phagocyte system (MPS) (7)

More recently, a bi-specific antibody, trontinemab, against TfR and A has been tested in non-human primates 94 and AD patients (NCT04023994)

Characterization of the blood brain barrier disruption in the photothrombotic stroke model