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Additionally, they secrete inflammatory cytokines like TNF-, IL-1, IL-6, and matrix metalloproteinases (MMPs), which contribute to bone damage (21, 22)

Nov 8, 2022

During the treatment, you can relax in a comfortable setting, with some patients even choosing to read or listen to music while they receive the therapy

However, given the continued popularity of the term NALFD, we will refer to the condition as such throughout the remainder of this paper

Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes