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If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.[4][7][9][12] The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency

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G., Kurth, T., Belanger, C., MacFadyen, J., & Gaziano, J

Last updated on Jul 13, 2026

For sustainable results, it should be integrated into a balanced plan that includes proper nutrition, exercise, and stress management