10.1371/journal.pone.0152034 Summary Keywords disease susceptibility, gene mutation, hereditable disease, phosphotyrosine, posttranslational modification, signal transduction, single nucleotide polymorphism Citation Hendriks WJAJ, van Cruchten RTP and Pulido R (2023) Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty
This has motivated in part the development histidine- and carboxylate-specific probes that can be used in parallel alongside of thiol-specific probes, which when jointly deployed, may well approach full coverage of the metalation status of the metalloproteome
While more research is needed to confirm long-term outcomes, current evidence supports its use in supervised clinical settings
Compatibility: Use only within research protocols that follow your labs SOPs and local regulations
Regulatory status will remain contingent on new data and prevailing evidence standards, as well as the absence of approved therapeutic uses to date
