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their effects may be modulated by levels of riboflavin, choline, betaine, and vitamin B12, as well as by gene-gene interactions

Peer review Peer review information Nature Communications thanks Kathrin Ulrich and John Mieyal for their contribution to the peer review of this work

NDT includes T4 and T3, along with T2 and T1

The 1950s brought further progress in developing peptide therapy

Studies show the peptide increases dendritic spine density by 40-60% in treated brain regions, with formation of new functional synaptic connections confirmed by electrophysiological recordings demonstrating enhanced synaptic transmission and long-term potentiation