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10.1016/j.pep.2025.106764 84 KumarF

Structural Reinforcement (Cytidine Modifications): m 5 C and ac 4 C serve as potent stabilizers by enhancing base-stacking and hydrogen-bonding thermostability, while hm 5 C introduces an additional layer of metabolic regulation

Since the 1980s, this research group has published extensively on EpitalON and related peptides, generating a substantial body of literature spanning cell culture studies, animal experiments, and small human trials

Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care

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