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Inhibition of ASK1 activity significantly inhibits the development of NASH

Most carotenoid molecules have a characteristic skeleton of 40 hydrocarbons with a system of conjugated double bonds

Johansson AS, Ridderstrm M, Mannervik B

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Besides, ISL treatment not only effectively reduced TNF- and IL-6 gene expression in LPS-induced mouse primary peritoneal macrophages but also attenuated lung and liver injuries induced by LPS, accompanied by decreased inflammatory responses, which may be strongly related to NF-B inhibition (Yang et al., 2021b)