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In the 12-week randomised controlled trial documented in the obesity pharmacotherapy literature, the 1 mg/day group achieved statistically meaningful separation from placebo

Some patients maintain steady weight loss for a full year, while others hit a plateau at month 3

Front Molecular Neurosci

Tsiolaki et al., 2018)

Figure 1 2.2 The LPA-LPAR signaling pathway LPAs diverse biological functions have earned it the designation multifunctional phosphate messenger. Since the first LPA receptor identification and cloning in 1996 (33), six specific LPA receptors (LPAR1-6) have been discovered, classified into two families (34, 35) ( Table 1 )