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Inadequate vitamin C intake seems to be associated with an increased risk of preeclampsia [219] and some studies have shown that peri-conceptional supplementation with multivitamins may lower the risk of preeclampsia in normal or under-weight women [220, 221]

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Similar microbial signatures have been observed in AD and MS, suggesting a shared microbiome-inflammation axis that contributes to disease pathophysiology [618, 619]

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This metabolic reprogramming leads to the continuous production and accumulation of large amounts of lactate, which in turn causes acidification of the TME, promoting cancer cell growth, migration, and angiogenesis ( In addition, glucose transport plays a crucial role in regulating tumor glycolysis