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Things that usually mean slow down: Stinging that lasts (not just a brief tingle)

While causality remains debated, GLP-1 receptor agonists associate with increased pancreatitis risk in some populations

Tirzepatide Research# SURPASS program (Type 2 diabetes): Five Phase 3 trials demonstrating superior HbA1c reduction compared to insulin glargine, semaglutide, and insulin degludec SURMOUNT program (Obesity): Phase 3 trials showing up to 20.9% weight loss at 72 weeks FDA approvals : Mounjaro (May 2022) for T2D

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Excess body weight has also been associated with gout