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GSTs lower the pKa of the GSH thiol group from approximately 9.0 to 6-7, increasing the proportion of reactive thiolate anion available for nucleophilic attack

Importantly, Babesia parasites have a life cycle that includes sexual reproduction in the midgut of their ixodid tick vectors, which eventually leads to transovarial transmission and the expansion of the parasites in the tick vectors

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For most patients, it resolves substantially after the first few weeks of a given dose