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Overall, the study provides compelling evidence that hyperthermia preferentially targets leukemic progenitor cells while sparing normal hematopoietic cells to a significant extent

Specifically, it downregulates genes and pathways related to DNA damage, OS, inflammation, and PANoptosis, while concurrently upregulating genes and signaling pathways associated with cell survival, including autophagy and mitophagy

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Some see it as a promising compound, while others are skeptical due to limited human trials

CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma