Methotrexate is an effective treatment for psoriasis-associated comorbidities, such as psoriatic arthritis due to its dual efficacy in modulating the immune response and reducing keratinocyte proliferation (Elango et al
LY294002 and SP600125 were from EMD (Gibbstown, NJ, USA) Western blot analysis The antibodies used for western blotting included those against stress-activated protein kinase (SAPK)/JNK, phospho-SAPK/JNK (Thr183/Tyr185), caspase-7, caspase-9, phospho-Bcl-2 (Ser70), and poly(ADP-ribose) polymerase (PARP) (Cell Signaling Technology, Danvers, MA, USA), cytochrome c and -actin (Sigma, St Louis, MO, USA), cytochrome oxidase subunit IV (Cox IV
Mandal and his team have instead proposed that the forming of oxidative stress aided by glutathione deficiency should be addressed to treat Alzheimer's disease, and not amyloid plaque
DHODH, Dihydroorotate dehydrogenase
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