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Patients should have a baseline complete blood cell count (to exclude lymphopenia) and liver enzyme testing, and they should be monitored for hypertension before and after initiation of therapy

The role of AOD-9604 in cartilage regeneration and joint health

In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

Most patients with thrombocytopenia due to portal hypertension have splenomegaly and, often, other features of portal hypertension such as esophageal varices