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However, research into the mechanisms of acetaminophen toxicity and the development of novel therapeutics is hampered by the lack of robust, reproducible, and cost-effective model systems
Among the members of the caspase family, caspase-3 is a crucial modulator of apoptosis in mammalian cells [42]
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SFN also induces a series of biological defense genes, including phase II detoxification/antioxidant enzymes and antioxidant molecules such as glutathione (GSH, L--glutamyl-L-cysteinyl-glycine), and suppresses inflammation via the inhibition of nuclear factor kappa B (NF-B) and the activation of the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) (17, 18)