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This is similar to studies where melatonin administration prevents sleep loss in PD patients and confers protective effects on mitochondria in mice and rat models of PD (Daneshvar Kakhaki et al

doi: 10.1007/s00401-016-1636-z 42 DaskalovA.MartinezD.CoustouV.El MammeriN.BerbonM.AndreasL

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

In my own practice, especially if an older person has risk factors for vitamin B12 deficiency, I consider a vitamin B12 level of 200-400 pg/mL borderline, and I usually order a methylmalonic acid level as a follow-up

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