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Parasite and disease control is critically dependent on interferon (IFN)-producing type 1 T helper (Th1) cells and macrophages expressing type 2 nitric oxide synthase (NOS2), whereas non-healing, chronic CL has been linked to the expansion of interleukin (IL)-4-secreting Th2 cells, IL-10-producing CD4 + T cells and the expression of arginase 1 (ARG1) (Bogdan et al, 2024

, 27 with a particular focus on recently identified peptides and their emerging applications in the management of IBD (Table 1)

In recent years, nanotechnology-based drug delivery systems have emerged as a particularly promising solution due to their unique ability to encapsulate both hydrophilic and lipophilic compounds

177 Significant heterogeneity exists between multifocal tumor nodules in HCC

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