Optimizing the cleavage conditions, such as enzyme concentration, temperature, and buffer composition, can also improve the efficiency of tag removal
Sterile fill-finish capacity is constrained and shared across many products competing for the same lines
Some mild nausea may occur, particularly in the first week of each dose increase
When melanocytes are damaged or destroyed, white patches may appear
Unlike other vertebrates (e.g., fish, amphibians, and birds), human RBCs lose their nuclei during their maturation process, an adaptation that favors the accumulation of ~250270 million copies of hemoglobin per mature erythrocyte at the expenses of de novo protein synthesis capacity