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Furthermore, inhibition of the AMPK/mTOR/ULK1 pathway reduces autophagy in OCs exposed to high levels of glucose [111], and activation of the PI3K/AKT/mTOR axis suppresses autophagy of OCs treated with hydrogen sulfide [108]

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Toxicity and efficacy evaluation of an adeno-associated virus vector expressing codon-optimized RPGR delivered by subretinal injection in a canine model of X-linked retinitis pigmentosa