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The previous, temporary ECM then transitions from a loose network of fibronectin tissue to a larger, denser collagen bundle

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7 Importantly, the capacity of stored RBC to regenerate 2,3-BPG and maintain ATP upon rewarming is tightly linked to their capacity to circulate in vivo after transfusion, a gold-standard parameter that assesses the quality of transfused blood, also referred to as post-transfusion recovery (PTR)