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Treatment plans are fine-tuned based on clinical progress, tolerance and safety markers to optimise outcomes while minimising risk

Moreover, it was demonstrated that T-2 toxin induced cytotoxicity in HeLa cells is mediated by generation of ROS leading to DNA damage and trans activation of p53 protein expression which leads to shift in the ratio of Bax/Bcl-2 in favour of apoptosis and subsequent release of Cyt-c from mitochondria followed by caspase cascade [99]

Rebalancing glutathione levels reduces chronic inflammation and restores immune function

Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling

Ferroptosis can therefore be induced by depriving cells of the sulfur-containing GSH precursor, cysteine, via inhibition of the system x c cystine/glutamate antiporter (e.g., using small molecules of the erastin family), or by direct inhibition of GPX4 itself (Forcina & Dixon, 2019)