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To assess the robustness of the findings, additional sensitivity analyses were performed using spline-based ANCOVA with cubic regression splines to accommodate potential non-linear relationships between age and metabolite abundance

Some of the most promising available treatments for the melasma are: elimination of causative factors, protection from UV radiations (with sunscreen application), and use of triple combination (hydroquinone, tretinoin, fluocinolone)

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Nerve damage involves inflammation, vascular compromise, neurotrophic factor deficiency, oxidative stress, and mitochondrial dysfunction

If discomfort occurs, reducing frequency or seeking professional advice may help