El K, et al
Both BMAC and MFAT deliver similar results, although BMAC is generally used for younger, bone-involved OA, while MFAT is considered a better fit for elderly patients and those with higher body weight
HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use
The consultation included an honest discussion of where the evidence was strong (topical applications, tissue repair contexts) and where it was thinner (systemic injectable use for aesthetic outcomes)
If you apply it that way, if you can get to the injury site, sometimes people will inject locally