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Tanshinone IIA loaded chitosan nanoparticles decrease toxicity of -amyloid peptide in a Caenorhabditis elegans model of Alzheimers disease

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442 Tetrodecadazinone (a novel tetrodecamycin-pyridazinone hybrid) reduced the ECM proteins (fibronectin and collagen I) and -smooth muscle actin (-SMA) levels by regulating TGF-1/Smad2/3 signaling pathway