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demonstrated that microalbuminuria is associated with maladaptive arterial remodeling and impaired arterial flow-mediated vasodilation due to endothelial dysfunction ( 3.2.2 White matter lesions CKD has been associated with structural brain changes, particularly WMLs ( 3.2.3 Uremic toxins Uremic toxins are believed to be the primary cause of cognitive impairment in CKD patients ( 3.2.4 Pro-inflammatory factors Appropriate activation of the inflammatory response is essential for defense against injuries, but if not properly regulated, deleterious effects may occur ( Under normal circumstances, peripheral tissues and the brain are separated from each other due to the intact blood BBB

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Discrepancies in study selection were resolved by consensus

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