M.S., I.B., H.Z., M.K.: Validation
His early research was focused on the sirtuins, which are protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in epigenetics, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer
Subsequent casecontrol association analysis confirmed that LONP1 increases CDH risk through de novo and inherited disruptive variants
Li J, Zhang L, Dang X, Su L, Jabeen K, Wang H, et al
Lastly, thought-provoking work into the mechanisms by which adult schistosomes release immunomodulatory factors into the host revealed that they are not restricted to proteins shed as part of the membrane, but that they also employ exosome-like vesicles that drive classical activation of macrophages (156158)