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Semaglutide achieves weight loss primarily through appetite suppression and metabolic regulation via central nervous system pathways

Kojima M, Hosoda H, Date Y, et al

Figure 2 shows the schematic diagram of ZAG function in adipose tissues

Patients should be advised to seek prompt medical evaluation for severe or persistent gastrointestinal symptoms, vision changes, unusual neck swelling or hoarseness, or severe constipation with abdominal distention

Semaglutide is a GLP-1 receptor agonist, and GLP-1 agonists also slow gastric emptying indeed, gastric slowing is a well-known component of how GLP-1 drugs lower postprandial glucose