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(2000b)

In this cMAK algorithm, the transcriptional, proteomic, and phosphoproteomic data of predicted kinases were wholly considered to reduce potentially false-positive hits, and predicted kinases with differentially regulated mRNAs at 2 time points, changed proteins at 1 time point, or altered phosphorylation sites at 1 time point were retained

These observations reinforce the need for well-designed randomised controlled trials (RCTs) to validate the findings and expand the evidence base

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