A Pragmatic Approach to Product Evaluation and Authorization It is worth considering the approach to premarket authorization recommended in the 2001 Institute of Medicine report Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction : In the absence of any claim of reduced exposure or reduced risk, manufacturers of tobacco products should be permitted to market new products or modify existing products without prior approval of the regulatory agency after informing the agency of the composition of the product and certifying that the product could not reasonably be expected to increase the risk of cancer, heart disease, pulmonary disease, adverse reproductive effects or other adverse health effects, compared to similar conventional tobacco products, as judged on the basis of the most current toxicological and epidemiological information
Smoking tobacco is already recognized to cause symptoms of cough, sputum, chronic bronchitis, wheezing, and shortness of breath
While a pack of fake Marlboros costs 20 cents to make in China, in the U.S
The standard of ten packs remains in the industry even in these cases
Others, while perhaps requiring disclosure of conflict of interest, say that the research should be based on the data itself, not the source
