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Free Radic Biol Med 56:226233

Anti-inflammatory peptides reduce swelling and improve lymphatic function, though lifestyle modifications including sleep position elevation, salt reduction, and allergy management prove equally important for comprehensive improvement alongside peptide treatment protocols

Sermorelin provides broad systemic GH benefits

Together, these data support a model in which adoptively transferred splenocytes from aged mice initiate a systemic inflammatory cascade, which in turn activates and expands endogenous tissue-resident macrophages, leading to sustained tissue functional impairment